2025 Indianapolis 500 betting, odds, predictions: 3 Indy 500 longshot picks at Indianapolis Motor Speedway

Pato O'Ward is the 5-1 favorite to win the 2025 Indianapolis 500 on Sunday. Although he has never won the Indy 500 and is winless over the first five races of the 2025 IndyCar schedule, it hasn't been the result of being overmatched. O'Ward has finished second in two of the last three Indy 500 races and although officially placed 24th in 2023, O'Ward was running towards the front before a late crash. The 26-year-old has finished sixth or better in five of his six Indianapolis 500 races and has finished second in two of five IndyCar competitions this year. Could the 2025 Indianapolis 500, which runs from Indianapolis Motor Speedway on Sunday at 12:45 p.m. ET, be the race to change both those unfortunate statistics for O'Ward?

Alex Palou (11-2) and Scott Dixon (13-2) follow O'Ward in the latest 2025 Indy 500 odds. The 2025 Indianapolis 500 starting lineup also features intriguing longshots, including Marcus Ericsson, who won the Indy 500 in 2022 but is going off at 20-1. Helio Castroneves (30-1) and Will Power (25-1) are other longshots who have won the Indianapolis 500, so should you include any of them in 2025 Indianapolis 500 betting? 

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Before entering any 2025 Indianapolis 500 picks, be sure to see the latest 2025 Indy 500 predictions from SportsLine's proven projection model. Developed by SportsLine predictive data engineer Mike McClure, the proprietary auto racing prediction model simulates every race 10,000 times and has nailed a whopping 21 NASCAR winners since 2021, including three winners in 2025. New users have the opportunity to take advantage of the latest DraftKings promo code and Fanatics Sportsbook promo code. Here are the three Indy 500 longshots to target, according to the model:

Best Indianapolis 500 longshots (odds subject to change):

• Kyle Larson (+1800)
• Conor Daly (+2500)
• Colton Herta (+2500)

Kyle Larson (+1800)

Larson started fifth last year, but he is much further back in the grid this year (19th). The 32-year-old had a bad restart in his debut, giving him something to learn from heading into the 2025 edition. He told reporters that this is the biggest event he has ever competed in, and he is attempting The Double again this year. Larson will look for a strong showing at Indianapolis Motor Speedway before heading to Charlotte for the Coca-Cola 600. He has three wins in his last seven NASCAR Cup Series races, and his talent makes him an intriguing longshot for the Indy 500 on Sunday. On DraftKings, you can use a DraftKings promo code to receive $300 in bonus bets with a winning $5 wager.

Conor Daly (+2500)

A native of the Indianapolis metro, Daly will have more than just the local support in his favor as he also brings an impressive slate of recent finishes to The Brickyard. After having an average finish of 23.4 over his first eight Indy 500 starts, Daly's average finish is 8.0 over his last three starts. Each of the three has been in the top 10, as he led for seven laps in 2022 and for 22 laps in 2024. Last year's performance came despite being in Row 10 on the starting grid, and now that he's on Row 4 this year, his prospects are even higher as an Indy longshot.

Colton Herta (+2500)

The 25-year-old finished second in the IndyCar standings last year and is already making his seventh start in the Indy 500. The race hasn't gone well for him recently as he's failed to finish two of his last three runs due to accidents or mechanical issues, but he also finished ninth in 2023. Herta has finished in the top seven in three of five races this year, including three of four non-road course events. Herta won the Grand Prix of Nashville in September at Nashville Superspeedway on an oval course, which is the same shape as he'll run at Indianapolis Motor Speedway, and at 25-1 odds, he's a longshot the model sees worth including in 2025 Indy 500 bets. The latest Caesars Sportsbook promo code "CBSDYW" lets you double your winnings on 10 straight bets.

More top Indianapolis 500 expert picks, longshots revealed

You've seen the Indy 500 longshots from the model. Now, see the full 2025 Indianapolis 500 leaderboard, including forecasts for who finishes first. Visit SportsLine to see the projected leaderboard, all from the model that has nailed 21 NASCAR winners, including three in 2025.

You can also view expert advice before locking in your Indianapolis Motor Speedway picks. Visit SportsLine now to see expert Steven Taranto's picks, including an epic longshot of over 70-1, all from an expert who has nailed 17 NASCAR winners.

Visit SportsLine now to see McClure's NASCAR advice as well, including the model's top picks for the 2025 Coca-Cola 600 on Sunday.

2025 Indianapolis 500 odds, drivers

See full 2025 Indy 500 picks at SportsLine

Pato O'Ward 5-1 
Alex Palou 11-2 
Scott Dixon 13-2 
Robert Shwartzman 8-1 
Takuma Sato 9-1 
Scott McLaughlin 9-1 
Josef Newgarden 19-2 
Felix Rosenqvist 12-1 
Kyle Larson 18-1 
David Malukas 18-1 
Alexander Rossi 18-1 
Christian Lundgaard 20-1 
Marcus Ericsson 20-1 
Kyle Kirkwood 25-1 
Conor Daly 25-1 
Colton Herta 25-1 
Will Power 25-1 
Santino Ferrucci 25-1 
Helio Castroneves 30-1 
Ed Carpenter 60-1 
Graham Rahal 80-1 
Sting Ray Robb 80-1 
Ryan Hunter-Reay 80-1 
Louis Foster 80-1 
Kyffin Simpson 100-1 
Jack Harvey 100-1 
Devlin DeFrancesco 100-1 
Christian Rasmussen 100-1 
Callum Ilott 100-1 
Rinus Veekay 100-1 
Nolan Siegel 100-1 
Marcus Armstrong 100-1 
Marco Andretti 100-1

Indianapolis 500 starting grid